The BioXplorer 100 is a bench-top, parallel 8 bioreactor platform, typically with 125 ml volume reactors. It is typically utilized in:
The latter stages of screening / early stages of process development
It has the same design, inputs, and outputs as larger systems, thus facilitating a greater number of investigative variables than a microplate or shake flask, but with an increased number of parallel samples than larger bioreactor systems. This combination of relatively high throughput with high information content enables better decision-making for scale-up and thus can speed up development.
The BioXplorer 100 is available as both a low- and high-pressure variant, enabling access to a wide range of applications ranging from standard gas fermentation and aerobic cultures to facilitating studies into decarbonizing high-pressure C1 gas fermentation.
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Features and Options
Vessel Types and Volumes
Reusable glass bioreactors are appropriate for a wide range of applications at atmospheric pressure.
All reactors are suitable for autoclaving, with auto-cleavable probes as standard.
Uniquely developed head plates to house all feeds and probes.
Working volumes ranging from 20 to 100 mL.
Bioreactor geometry that mimics production-scale systems.
-50 ⁰C to 250 ⁰C as standard (circulator dependent).
Fine temperature control, with fluctuations normally lower than ±0.05 ⁰C
Stainless steel reactors for standard or elevated pressure (up to 10 bar/145 PSI) fermentations.
Through active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU.
Temperature, pressure, pH, DO, turbidity, conductivity.
Optional: Integration of third-party probes, such as in-situ FTIR, particle sizing probes, and Raman probes.
250 up to 1500 rpm via suspended magnetic agitation.
0 up to 1500 rpm via overhead stirring.
Through fully automated liquid and gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.
All relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system
Intelligent Software Control and Analysis
The labCONSOL control software from H.E.L operates the BioXplorer 100 system, thereby allowing complicated, completely automated experiments to run without the need to be monitored. This allows:Multi reactor control with unrestricted step recipe planning, where plans can be altered at any time without process interruption
User defined data logging with customizable tabular and graphical displays
Starting and stopping reactors simultaneously or individually
Export data functions and integration with in-house record keeping systems and electronic lab notebooks
Include automatic user-configurable reaction monitoring and shutdown procedures, to ensure user safety.
Automatic hardware and software fail-safes are installed on every system.