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ASU | Automated Liquid Sampling Unit

The Automated Sampling Unit (ASU) enables direct, online, automated sampling of liquids or slurries from reactor systems. It supports extraction of up to 6 samples per unit, ranging from 0.2 to 2 ml in sample volume, at user-defined intervals. It is completely integrated with H.E.L’s powerful labCONSOL control platform, enabling it to be used seamlessly with H.E.L’s reactor systems, on both small and large vessels. It also has options for incorporating quenching and dilution, enabling full automation of the experimental procedure and thus releasing operators to focus on other responsibilities, effectively accelerating development time.


The AutoMATE is a highly versatile, linear, automated parallel synthesis platform, for use in general chemical synthesis within R&D and process development, as well as more bespoke applications. As with the PolyBLOCK, the independently controlled reaction zones make AutoMATE especially well-suited for DoE campaigns and the platform’s modular design allows for an easy expansion of capabilities. In particular, the linear reactor design of the AutoMATE makes it ideal for more demanding applications, such as where multiple inputs and outputs are required.

Application modules that can be added include:

Solubility/crystallization monitoring
Online calorimetry option
Catalyst screening
The platform supports reactor volumes of up to 500 ml per reactor and is equipped with adaptors to support a range of reactor types and sizes, including integration with H.E.L’s catalyst screening CAT reactor blocks. Additional functionality modules include:

Liquid dosing
Gas feed
Liquid sampling, including integration with the ASU
Quick-connect refluxing option
Quick-connect inerting solution
pH monitoring


The BTC-130 (Battery Testing Calorimeter) is a bench-scale adiabatic calorimeter designed to enable the testing of thermal, electrical, and mechanical stress tests on smaller-sized battery cells. Evaluation of these tests facilitates the assessment of the safety performance of battery cells, the battery’s safe operating limits, and research and development into the mechanisms of thermal runaway. The BTC-130 also supports the use of small-volume spherical test cells, enabling thermal stability screening of individual battery cell components under adiabatic conditions.

BioXplorer 100

The BioXplorer 100 is a bench-top, parallel 8 bioreactor platform, typically with 125 ml volume reactors. It is typically utilized in:

The latter stages of screening / early stages of process development
It has the same design, inputs, and outputs as larger systems, thus facilitating a greater number of investigative variables than a microplate or shake flask, but with an increased number of parallel samples than larger bioreactor systems. This combination of relatively high throughput with high information content enables better decision-making for scale-up and thus can speed up development.

The BioXplorer 100 is available as both a low- and high-pressure variant, enabling access to a wide range of applications ranging from standard gas fermentation and aerobic cultures to facilitating studies into decarbonizing high-pressure C1 gas fermentation.

BioXplorer 5000

The BioXplorer 5000 bioreactor is ideally suited to drive your cell culture scale-up efficiency while staying on the bench. With culture volumes between 500 ml and 20 L, the BioXplorer 5000 provides fully automated control of your cell culture.

The systems are available either in standard configurations or can be customized to meet your requirements. With our open system architecture and flexible software offering simple upgrade and integration options.

The BioXplorer 5000 range is ideal for:

Microbial and mammalian cell culture and gas fermentation
Elevated (high) pressure design optional
Process development and optimization and scale-up studies
Increase your process knowledge and take advantage of an exhaustive list of standard options and innovative features including automated inventory monitoring, online cell density analysis, and automatic KLa determination. You can also add specific gas feeds to run cultures at elevated pressures, under aerobic or anaerobic conditions, ideal for C1 gas studies.


The ChemSCAN is a bench-top, automated parallel catalyst screening platform, designed for the rapid screening of high-pressure reactions and catalysts. The 4 reactor variant, supports reactors ranging from 16ml to 500ml. As with the fully automated ChemSCAN, each stirred reactor is independently controlled and monitored, allowing screening tests to be carried out concurrently and accelerating development time.


The FlowCAT is an automated high-pressure flow catalysis bench-top platform, designed for the development of continuous flow chemical processes. It supports both gas and liquid feeds, and so can facilitate the scale-up of both homogenous and heterogenous chemistries.


The Phi-TEC II is an adiabatic calorimeter, which supports the use of low Phi-factor test cells. This allows for manufacturing plant conditions to be fully replicated on a lab scale thus allowing thermal runaway risks to be simulated and assessed. Utilizing low-Phi factor cells means that the runaway rate is not tempered by the test equipment, and subsequently, the measured rate of pressure increase and final temperature (Tend) – along with the calculated Time to Maximum Rate (TMRd) and adiabatic temperature rise (∆Tad,d) – are representative of what would be expected to occur during a production-scale incident

The impact of different operating scenarios can be explored using the Phi-TEC II, and the data generated can be utilized to determine appropriate safety controls for the manufacturing plant, such as:

Emergency and evaporation cooling
Controlled depressurization
Vent sizing (in accordance with DIERS methodology)
Thus, the Phi-TEC II enables hazards to be fully evaluated, enabling their mitigation prior to scale-up.


Process Development Reaction Calorimeter

The Simular is a reaction calorimeter that is used within process development to investigate the thermal properties of a chemical reaction under the proposed operating conditions. The Simular allows for the optimization of process conditions for maximum product yield and minimal safety hazards, based on the derived thermodynamic and kinetic information of the reaction.

The Simular enables the determination of the plant cooling capacity required to keep a reaction isothermal (Tp), and the calculation of the maximum temperature the main reaction will reach in the event of a thermal runaway. The parameter known as the Maximum Temperature of Synthesis Reaction (MTSR) is a critical value in determining whether the emergency cooling capacity in a plant is capable of dealing with an increase in temperature. The Simular can be used to determine safer reaction conditions.

The Simular supports both the classical heat flow calorimetry method, and the quicker, more efficient, calibration-free power compensation calorimetry method, allowing selection of the most appropriate method for the scenario that is of interest.

Tandem Off Gas Analyzers

The Tandem gas analyzer systems will give you real-time, on-line data that helps you understand and control your cell culture experiments. Specifically designed for CO2 and O2 exhaust gas analysis from cell culture experiments, the tandem range fits onto a wide range of systems, from different manufacturers.

Key Features
– Get deeper understanding of your cell cultures on-line
– With greater control, increase the reliability and repeatability of your process
– Automate your processes and controls, based on real-time feedback
– Flexible design allows the same data to be recovered from all your reactors


Faster product development, testing, and launch through scientifically robust data:

Reveal battery heat-release profiles for an optimised battery management system

Understand performance consequences of use, misuse, and cell aging

Define effects of environment temperature on battery heat generation to ensure product performance and safety

The new iso-BTC+, is designed for measuring heat-release profiles during battery charge and discharge testing, giving you enhanced performance and lifespan data. Building on established capabilities of the smaller iso-BTC, the new iso-BTC+ allows for testing of even higher power and physically larger batteries.

This performance data will better inform the efficient design of thermal management systems; yielding safer, higher-performing products. A deeper understanding of battery thermal behavior can also enhance thermal propagation modeling/simulations leading to time savings during battery and product testing.

The iso-BTC+ work with a range of cyclers and battery formats to precisely quantify the thermal behavior of batteries during real-world use conditions. Electrical and thermal measurements are made simultaneously at defined temperatures, including charge/discharge profiles, all controlled by versatile and easy-to-use software.


H.E.L’s fully customizable AutoLAB reactor platforms are designed, configured, and tailored to meet your specific process and application requirements. The modular and highly adaptable nature of the system enables the platform to evolve with your research and development interests.


The BTC-130 (Battery Testing Calorimeter) is a bench-scale adiabatic calorimeter designed to enable the testing of thermal, electrical, and mechanical stress tests on smaller-sized battery cells. Evaluation of these tests facilitates the assessment of the safety performance of battery cells, the battery’s safe operating limits, and research and development into the mechanisms of thermal runaway. The BTC-130 also supports the use of small-volume spherical test cells, enabling thermal stability screening of individual battery cell components under adiabatic conditions.


BioVIS is a probe for the inline monitoring of total cell growth and biomass within a bioreactor, enabling culture growth kinetics to be tracked and logged. It removes or reduces the need for online sampling, thereby simplifying measurements, reducing contamination risks, and conserving the culture media volume.

The probe can be produced at any length, making it suitable for any desired vessel size, and it is compatible with all major brands of bioreactors. The BioVIS Multiplex is designed for use with multiple bioreactors, enabling total cell density to be tracked across all parallel cultures

BioXplorer 400

The BioXplorer 400 boosts productivity and enables screening of cell culture conditions in larger culture volumes. The modular design and extensive list of options make the BioXplorer 400 adaptable to a wide range of applications, including microbial fermentation, C1 Gas fermentation and cell culture. This makes the BioXplorer 400 suitable for process development, Design of Experiment (DoE) studies, or essential research.

With fully automated control of either four or eight bioreactors, the BioXplorer 400 supports cell culture working volumes of between 20 ml and 400 ml. The individual control of each reactor enables the running of replicate samples with unique conditions, or any combination that your experiment requires. Multiple systems can be run from the same control PC for extended experiments.


– Parallel processing of 4 independent reactors, in a small footprint
– Choice of reactor sizes and types including elevated pressure design (5 bar or 10 bar options)
– Fully automated parallel processing of up to 4 independent reactors
– Integrated individual liquid and gas feeds with options for gas mixing

Catalyst Screening Platforms

Our complete range of multi-sample high throughput catalyst screening vessels has been designed to provide a simple easy-to-use tool for high-pressure reaction screening. They can be used directly with stirring hotplates or oil baths.

CAT 7, 18, and 24: The CAT 7, 18, and 24 are manual catalyst screening reactors, supporting 7, 18, and 24 vials, respectively.

DigiCAT: This configuration of digital stirred-hot plate plus gas manifold can be used with CAT 7, 18 and 24 as well as other reactors (16-75 ml).

DigiCAT 96: The DigiCAT 96 is an automated catalyst screening platform that supports a standard 96-well Zinsser block for high throughput screening early on in catalyst development.

PolyCAT 4 and PolyCAT 8: The PolyCAT 4 and 8 are bench-top, automated parallel catalyst screening platform, designed for the rapid screening of high-pressure reactions and catalysts.


The CrystalSCAN is a bench-top, automated, parallel crystallization monitoring platform, facilitating the determination of solubility curves and the MSZW (metastable zone width) of multiple samples, and optimization of the desired crystallization process. The standard system supports 8, independently controlled reactors, each equipped with H.E.L’s proprietary crystallization monitoring probe, CrystalEYES.

In addition to automated stirring, heating, and cooling of each sample, the CrystalSCAN can automatically add the solvent/anti-solvent of choice, diluting each sample independently at the end of each cycle. Consequently, data on the points of dissolution and the points of nucleation can be determined automatically under a range of experimental conditions, enabling solubility curves to be generated and the characterization of MSZW, respectively. While the former provides the basis for optimizing the desired crystallization process, the latter provides insights into the behavior of the process on larger scales, informing and facilitating process development.

This combination of high throughput, coupled with high data content, accelerates the development and optimization of the desired crystallization process and shortens time to commercialization.


The Phi-TEC I is an adiabatic calorimeter that enables the characterization of thermal runaway hazards during process development and scale-up. The Phi-TEC I replicates industrial (large volume) conditions on a lab scale, enabling thermal runaway hazards to be characterized safely and efficiently.
Via direct sample temperature measurement and by rapidly responding to any thermal changes, the Phi-TEC I accurately tracks exothermic events and maintains adiabatic conditions. This adiabatic screening enables thermal events to be defined with the accurate characterization of the onset temperature (Td) and facilitates the calculation of other key parameters, such as the rate of pressure change, the adiabatic temperature rise (∆Tad,d), and the time to maximum rate (TMRd).


Key Features
– 4 or 8 Independent reaction zones
– Independent temperature control (100 °C difference between zones, temperature range of -60 °C to +225 °C)
– Independent agitation control (250 to 1500 rpm, suspended mechanical or overhead stirring available)
– Small footprint – no larger than a typical laboratory notebook
– Use any combination of reaction vessels on one platform
– Intuitive control software with choice of interfaces

Designed to maximize your laboratory’s productivity, parallel synthesis technologies with PolyBLOCK is easy to use, flexible and compact multi-reactor system.

With either four (PolyBLOCK 4) or eight (PolyBLOCK 8) independently controlled and monitored zones, PolyBLOCK 4 offers working volumes of up to 500 ml and PolyBLOCK 8 up to 120 ml. Reactor options range from 1 ml HPLC vials to round or flat-bottom flasks up to 250 ml and custom reaction vessels up to 500 ml.

Agitation in each zone is independently controlled and temperature monitoring and control are offered with either reactor and/or zone temperature.

TSu Thermal Screening Unit

Thermal and Pressure Hazard Screening Platform

The fast screening of thermal hazards can be performed with the Thermal Screening Unit (TSu). It uses samples typical from 0.5 to 5g, will generate both temperature pressure data, and hence can be considered a better alternative to classical DSC/DTA methods.


The iso-BTC (Battery Testing Calorimeter) is an isothermal calorimeter designed for the characterization of thermal behavior and electrical performance of battery cells under normal and extended use conditions. It supports a range of adaptors which allows a wide range of cell formats to be analyzed.

The iso-BTC supports the full integration of a charge-discharge unit, allowing for the repeated, automated cycling of battery cells under a range of operating conditions, while concurrently recording both the battery’s electrical performance and the heat evolved. It can also conduct accelerated aging tests, allowing the effect of battery aging on cell performance to be investigated. Battery chemistry, electrode composition, and battery cell type can also be investigated within cell development using the iso-BTC.

Thermal mapping (multipoint temperature measurement) allows the user to identify regions of a battery that generate greater thermal energy to be highlighted. Along with the thermal behavior characterization of the battery cell over a range of temperatures and (dis)charge rates, this information can be used to inform effective and targeted thermal management strategies within the battery module and pack.

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